A Simple, accurate, precise and economical procedure for simultaneous estimation of Amlodipine besylate and Indapamide in combined tablet dosage form by UV spectrophotometry, using Multicomponent mode of analysis. The method is based upon determination of Amlodipine besylate at 238 nm and Indapamide at 242 nm in methanol at their respective λmax. Developed method was validated according to ICH guidelines. The calibration graph follows Beer’s law in the range of 5 to 25 μg/ml for Amlodipine besylate and 2 to 8 μg/ml for Indapamide with R square value greater than 0.999. Accuracy of all methods was determined by recovery studies and showed % recovery between 99 to 103 %. Intraday and interday precision was checked for all methods and mean %RSD was found to be less than 2 for all the methods. The methods were successfully applied for estimation of Amlodipine besylate and Indapamide in marketed formulation.
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